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53 In fact, almost all selumetinib-treated patients showed no tumour progression while being treated with the drug, with 72% showing a partial response and 24% showing stable disease in the SPRINT trial (NCT01362803)

[21] SODs catalyze the production of O 2 and H 2 O 2 from superoxide (O 2 ), which results in less harmful reactants

doi: 10.1515/jpem.2008.21.11.1057

With the accumulation of ROS (oxygen free radicals such as superoxide anion radical and hydroxyl radical), the endogenous antioxidant defense system (i.e., superoxide dismutase, catalase, glutathione ascorbate) fails to counteract ROS generation, resulting in an increase in oxidative stress (28, 33)

In addition to the review studies, several research groups have set up field experiments to reduce the effects of salt stress by applying exogenous SA