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In colitis models, LXR activation increases colonic crypt cell proliferation and colon length, indicating its pro-regenerative role in response to intestinal injury (148)

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[37] In carotid artery plaques from type 2 diabetic subjects, modification of endothelial cell proteins by the hexosamine pathway is also significantly increased

We identified 18 sequence variants associated with NAFL and 4 with cirrhosis, and found rare, protective, predicted loss-of-function variants in MTARC1 and GPAM , underscoring them as potential drug targets