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Administration of this nanoparticle, combined with the PD-L1 antibody, has polarised the M towards the M1 phenotype, which further leads to a reduction in inflammation, immunosuppressive activity, and pro-tumour signalling by downregulating NF-B and STAT3

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Aside from low skin-to-sun exposure, other factors of vitamin D deficiency include a poor diet low in oily fish, and vitamin D-related gene polymorphisms

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