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While this positions cagrilintide as slightly less potent in vitro than salmon calcitonin (sCT, pEC ~1112), its superior stability, reduced aggregation risk, and long acting pharmacokinetic profile make it far more practical for sustained receptor engagement in both animal models and clinical investigation

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Based on the aforementioned clustering result, each cluster was further segmented into sub-clusters, and the average gene expression within each sub-cluster was computed