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(2021) 184:413753.e14

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The FDA has given Generally Recognized as Safe (GRAS) status to 9 food colors: However, many of the nine currently approved dyes have raised public health concerns as they are likely carcinogenic, cause hypersensitivity and behavioral problems, or are inadequately tested (Kobylewski & Jacobson, 2010)

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Abbreviations NMN: (nicotinamide mononucleotide) ALD: (Alcoholic liver disease) NAD + : (Nicotinamide adenine dinucleotide) SIRT1: (Sirtuin 1) NMNAT: (Nicotinamide mononucleotide adenylyl transferase) NAMPT: (Nicotinamide Phosphoribosyltransferase) CYP2E1: (Cytochrome P-450 2E1) ALT: (Alanine aminotransferase) AST: (Aspartate aminotransferase) TC: (Cholesterol) TG: (Triglyceride) MDA: (Malondialdehyde) SOD: (Superoxide dismutase) GSH: (Glutathione) PCR: (Polymerase Chain Reaction) WB: (Western Blotting ) ELISA: (Enzyme-Linked Immunosorbent Assay) HE: (Hematoxylin-eosin) TNF-: (Tumor necrosis factor-) IL-6: (Interleukin-6) IL-1: (Interleukin-1) ROS: (Reactive oxygen species) GAPDH: (Glyceraldehyde-3-phosphate dehydrogenase) ATP: (Adenosine Triphosphate) ADP: (Adenosine Diphosphate) ZO-1: (Zonula Occludens-1 Protein) PMSF: (Phenylmethylsulfonyl fluoride) RIPA: (Radio immunoprecipitation assay) SDS: (Sodium dodecyl sulfate) TEMED: (Tetramethylethylenediamine) TBST: (Tris-Buffered Saline with Tween-20) PVDF: (Polyvinylidene fluoride) TBS: (Tris Buffered Saline) SDS-PAGE: (Sodium dodecyl sulfate - polyacrylamide gelelectrophoresis) References Lim SS, Vos T, Flaxman AD et al

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Photo-oxidative damage occurs when incident light reacts with a tissue chromophore such as a UV filter, which then attains an excited state

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