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Design of yeast-secreted albumin derivatives for human therapy: Biological and antiviral properties of a serum albumin-CD4 genetic conjugate

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Upon activation, caspase-1 enzymatically processes the precursor pro-interleukin-1 (pro-IL-1) into its biologically active form, mature IL-1, which is then secreted into the extracellular milieu, triggering a robust inflammatory response ( Moreover, MSU triggers the release of pro-inflammatory cytokines, such as interleukin-6 (IL-6), through the NF-B and Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling cascades, consequently amplifying the infiltration of inflammatory cells ( Figure 1 )

10.1111/imr.12910 Immunol

Conversely, defective autophagy exacerbates inflammatory responses, further aggravating insulin resistance in women with PCOS ( 3.3 Ferroptosis Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, may play a key role in the pathogenesis of PCOS