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Reduced peripheral blood mitochondrial DNA copy number as identification biomarker of suspected arsenic-induced liver damage

Mitochondrial metabolism also contributes to ferroptotic sensitivity through nutrient utilization and bioenergetic rewiring.Glutamine is essential for ferroptosis, and glutamine synthase 2 (GLS2), a key regulator of glutaminolysis, has been demonstrated to promote ferroptosis [90]

Its main clinical utility may lie in identifying a subset of IBD patients with a prominent eosinophilic component

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Together, tryptophan derived metabolites from the kynurenine pathway, such as kynurenic and xanthurenic acid, may have protective effects on IBD, whereas kynurenine may have the opposite effects

And in mutants of gpx-1 and gpx-4 , we observed another pattern of injury response, debris formation, in addition to axonal regrowth and axonal fusion (Fig