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18 TGF- functions through its interaction with TGF- receptors, which phosphorylate SMAD2/3, allowing these proteins to form complexes with SMAD4 that translocate to the nucleus and regulate gene expression

The source data underlying Figs

This article is for research and educational reference only

New, more effective molecules with optimized pharmacokinetics produce greater weight loss and some may be more effective for various metabolic disorders, through incorporation of one or more additional peptide epitopes