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Given the clinical relevance of neurons in NPC disease, we performed experiments in the human neuroblastoma SH-SY5Y cell line, which displays many biochemical and functional properties of human neurons and has been widely used as a model for neurodegenerative diseases

MOTS-c disc research: The direct evidence of MOTS-c preserving disc height and reducing degeneration in animal models positions it as one of the most promising candidates for future clinical development specifically targeting disc disease

Physiol Rev 98:25712606 Roslan A, Said DS, Sulaiman N, Mohd Ghani KA, Nurdin A (2023) Cluster of differentiation 147 (CD147) as potential membrane protein biomarker for bladder cancer cells

Denuded oocytes were fixed in 4% paraformaldehyde (PFA) for 30 min, followed by incubation in PBS containing 0.5% TritonX-100 for 30 min

Bacopa monnieri alleviates paraquat induced toxicity in Drosophila by inhibiting jnk mediated apoptosis through improved mitochondrial function and redox stabilization

This study establishes a causal relationship between phase separation dynamics and inflammasome signalling, proposing the targeted modulation of the phase separation interface as a potential therapeutic paradigm for the treatment of NLRP3-driven pathologies such as sepsis