glutathione and glutamate cysteine ligase cylindrospermopson Mode of action of Amino acid Precursors (GAP) functions The Impact of Genetic Polymorphisms

P., Chi, J

Research indicates that oxidative stress (OS), inflammatory responses, and lipid metabolic disturbances induced by alcohol and its metabolites are primary contributors to hepatocyte injury, positioning OS as a key target in ALD treatment

Normally microglia are neuroprotective, cleaning out debris that may contribute to neurodegenerative diseases or damage from ischemic stroke, but in the case of TBI they can become overactivated and exacerbate neuroinflammation (with upregulated TNFa, IL-6, C3, NK-kB, CD68, etc), and vascular changes can result in headaches, neurovascular flow changes, impaired lymphatic flow, blood-brain barrier disruption, activation of pro-inflammatory pathways, neuronal death, hyperexcitability, and disrupted synaptic connections

10.1016/j.molmed.2019.07.002 Trends Mol

doi: 10.1523/jneurosci.17-14-05316.1997 54 DoucetC.ErnouI.ZhangY.LlenseJ

The observed increase in phagocytosis due to CBD is thought to be related to the TRP-mediated increase in the influx of Ca 2+ (Hassan et al., 2014)