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Especially beneficial for individuals with fatigue, brain fog, or absorption issues

Results Excluding duplicates, 9288 titles and abstracts were screened and 228 full texts assessed (see supplementary figure 1)

Pain 18 , 15421550 (2017)

doi:10.1016/j.coph.2008.12.014

Therefore, we recommend that companies determine their regulatory pathway to market in 2025-2026 and consider pre-subs in 2026 to allow time to take action on any FDA feedback before submitting the premarket submission