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1b), in line with the recent finding of a critical role for polyamine in determining T H 17 differentiation 10,11,12

10.1016/s1474-4422(21)00030-2 Lancet Neurol

Chaudhary, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Areas like the underarms, neck, back of knees, inner thighs, perineal area, and anus are especially pigment-prone and may darken over time due to these factors

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Paracrine Regulation and Microenvironment Melanocytes are known to be closely associated with keratinocytes and fibroblasts, as they secrete many factors that modulate the function of melanocytes, reduce oxidative damage, and maintain their survival