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The term overmethylation is somewhat misleading

The substantial decrease in pyocyanin levels and biofilm formation in the PmtA-deficient pmtA strains suggests that this strain is less able to influence the host immune response and thus would be less able to establish a persistent infection

Nuclear staining was performed using DAPI

5.3.4 Methyl Transferases While glucuronidation, glutathionation, sulfonylation, as well as several other Phase II metabolism pathways increase the water-solubility of drugs, processes such as methylation (and acetylation below) do not substantially alter values such as LogP

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A recent report suggested that nonthermal plasma may be able to similarly redox cycle iron and perhaps induce ferroptosis through this class 4 mechanism [16]