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Aging 12, 55395550

doi: 10.1126/science.1241165 90 SpaggiariG.BriganteG.De VincentisS.CattiniU.RoliL.De SantisM

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CCR9 + Tfh cells specifically express Bcl-6, ICOS and other inflammatory mediators, including IL-7, IL-21, and IFN- (86)

5 Discussion and perspectives In recent years, in OA, a complex degenerative joint disease, increasing research indicates that ferroptosis not only exists in the pathological process but is also closely related to pathological features such as articular cartilage degeneration, synovial inflammation, and subchondral bone changes