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Bhattacharjee and Borah found that mitochondrial dysfunction and the development of oxidative stress could be the potential mechanisms for homocysteine-induced degeneration of dopaminergic neurons in the SN in the rat model of PD (Bhattacharjee and Borah 2016)

Whole exome approaches have identified heterozygous somatic mutations in the mediator complex subunit 12 (MED12) [10]

Therefore, the review suggests that, to improve FM symptoms, physical exercise and an energy deficit are necessary, as elevated BMI levels have been directly linked to increased pain and functional status in FM patients [28]

Pterostilbene and Neurodegenerative Diseases Polyphenols are organic metabolites present in plants (Cory et al., 2018) and widely distributed in a variety of dietary sources (Kim et al., 2009): fruits, vegetables, legumes, whole grains, seeds, nuts, extra virgin olive oil, red wine, coffee, tea, chocolate, herbs and spices (Rusconi and Conti, 2010