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The adjuvant use dosages of Leukine in clinical trials are generally much smaller than dosages for indications in the FDA-approved labeling

Vegetarians and vegans : B12 is found predominantly in animal products, so individuals following plant-based diets may be at risk of deficiency

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Where efficacy studies have shown higher protection rates in cats vaccinated with adjuvanted vaccines versus non-adjuvanted vaccines, the former are preferable in cats at high risk of infection