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Preclinical and clinical advances of GalNAc-decorated nucleic acid therapeutics

In the Phase 2 obesity trial published in the New England Journal of Medicine, the highest arm reached 24.2 percent average body weight loss at 48 weeks, and the curve had not flattened by the end

Yeh et al., 2007

Studies using animals show that the long-term effects of cortisol can affect individual markers of oxidative stress (19, 20, 9294)

Nat Rev Neurol 11:157165

Within this network, endothelial activation and upregulation of cell adhesion molecules serve as critical downstream effectors that spatially organize leukocyte recruitment, propagate microvascular obstruction, and exacerbate tissue hypoxia