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Metformin improves ovarian follicle dynamics by reducing theca cell proliferation and cyp-17 expression in an androgenized rat model

and overactivity of the hexosamine pathway

NEJM Evid

Astrocytes take up K + in areas with high concentrations through gap junctions between adjacent cells and release it in areas with lower concentrations (78, 81)

doi: 10.3389/fendo.2026.1781679 Received 06 January 2026 Revised 16 February 2026 Accepted 19 February 2026 Published 11 March 2026 Volume 17 - 2026 Edited by Alpo Juhani Vuorio, University of Helsinki, Finland Reviewed by Diana Rodrguez Vera, Instituto Politecnico Nacional, Mexico Nana Afia Ntim, University of Ghana, Ghana Updates Copyright 2026 Zhu, Qu, Li, Deng, Shen and Chen

a combination of 1 mM IBMX, 1 M dexamethasone, and 10 g/ml of insulin in media were added to fully confluent 3T3-L1 fibroblasts for three days (days 0-3) to initiate differentiation