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Hendrik Muller Award for Outstanding Research in the Social and Behavioral Sciences, N etherlands Royal Academy for the Sciences , 2005

Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

Parletta, N., Milte, C

Aging activates nicotinamide-adenine dinucleotide phosphate (NADPH) oxidase, xantine oxidase, cyclooxygenase and mitochondrial electron transport and inactivates the antioxidant system, including superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase, leading to an increase in ROS production and decrease in ROS degradation