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Sonne, D

K., Wolfe, K., Patel, B., Thewissen, R., Zaborina, O., & Alverdy, J

Front Neurosci 14: 670, 2020

Additional hallmarks include reduced mitogenic activity, overproduction of reactive oxygen species (ROS), reduced concentrations over time of growth factors, and decreased levels of tissue inhibitors of metalloproteinases (TIMPs) compared to acute wounds, and impaired angiogenesis