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doi: 10.1046/j.1471-4159.2002.01263.x

Studies in DSS and TNBS mouse models as well as in vitro experiments have shown that amino acids not only serve as substrates for energy production and biosynthesis, but also influence the M1/M2 macrophage balance through metabolic pathways, thereby regulating intestinal inflammation

Consequently, the diagnosis of HTN and DM mediated by OS should consider an epigenetic perspective while factoring in the lifestyle of the target population