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Fishel, F

To address this knowledge gap, we have developed a series of genetic models that permit spatiotemporal control over the expression of GCLC, the rate-limiting enzyme in GSH synthesis

10.1038/sj.emboj.7601623 Embo J

& Gebel, H

An honest side-by-side for researchers who care about what's in the vial Yes

30 The activation of genes responsible for antioxidant defense (e.g., the glutathione (GSH) system, 8 coenzyme Q10 (CoQ10) system, 31,32 and the nuclear factor, erythroid 2-like 2 (NFE2L2, also known as NRF2) transcription pathway 33 ) and membrane repair (e.g., the endosomal sorting complexes required for transport (ESCRT)-III pathway 34 ) limit membrane damage during ferroptosis (Fig