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In all these cases, the underlying issue is the overactivity of melanin pathways , which leads to darker patches compared to the surrounding skin

Have had a stomach or intestinal surgery, including weight loss surgery that removes part of the stomach or intestine (i.e., sleeve gastrectomy or gastric bypass)

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The peptide increased expression of growth factors including VEGF and FGF-2 in healing tendons

Ice crystal formation can disrupt peptide structure, particularly in solutions without cryoprotectants like glycerol

However, the therapeutic use of the native peptide is restricted by its short plasma half-life