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injections of 10 nmol kg 1 semaglutide ( n = 8 mice), 100 nmol kg 1 GLP-1MK-801 ( n = 8 mice) or vehicle (isotonic saline, n = 8 mice) at a volume of 5 l g 1

Superoxide dismutase (SOD) catalyses the dismutation of superoxide ion (O 2 ) to molecular oxygen (O 2 ) and H 2 O 2 (a less reactive species) (Reference Krishnamurthy and Wadhwani20)

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As induced by either selective small-molecule inhibitor iFSP1 or genetic deletion, FSP1 loss-of-function promotes ferroptosis

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Under these conditions, HT-1080 cells adopted a distinct morphology and were characterized by increased levels of CD44 and ferritin together with upregulated mesenchymal markers (Extended Data Fig