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doi: 10.1016/j.mce.2020.111003 161 ChengYLiWGuiRWangCSongJWangZet al

Combat Aging with CJC-1295 & Ipamorelin Understanding CJC-1295 and Ipamorelin CJC-1295 is a growth hormone-releasing hormone (GHRH) analog that stimulates the pituitary gland to increase HGH production

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The pituitary is governed by two opposing forces: GHRH (which stimulates GH release) and somatostatin (which stops it)

On some embodiments, an LNP may have an encapsulation efficiency of less than about 100%, less than about 95%, less than about 85%, less than about 80%, less than about 75%, less than about 70%, less than about 65%, less than about 60%, less than about 55%, less than about 50%, less than about 45%, less than about 40%, less than about 35%, less than about 30%, less than about 25%, less than about 20%, less than about 15% less than about 10%, or less than 5%

Its primary pharmacological characterization was published in European Journal of Endocrinology (PMID 9849822), where the authors identified it as the first growth-hormone-secretagogue receptor (GHSR-1a) agonist achieving GH-release selectivity comparable to GHRH in animal models