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Experimental studies using CD mouse models reveal that IRGM (Irgm1 in mice) exerts protective effects through multiple mechanisms: it disrupts NLRP3 and ASC oligomerization, inhibits inflammasome assembly, and mediates selective autophagic degradation of NLRP3 and ASC components [20]

Im in the same boat as your son At least with the anxiety/autoimmune/leaky gut issue

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While these compounds principally target GPX4, they might also exert effects on TXNRD1 in A549 and H1975 cancer cells [217]

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