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Potentially pathogenic airway bacteria and neutrophilic inflammation in treatment resistant severe asthma

Clinically, PD is distinguished by movement impairments such as bradykinesia, rigidity, dystonia, and postural instability [99]

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( 20:1103 ) Li S, Yang C, Wang W et al (2024) First-in-human study to assess the safety, tolerability, and pharmacokinetics of intravenous SHPL-49 following single- and multiple-ascending-dose administration in healthy adults

This results from a tyramine-induced depletion of norepinephrine normally present in the readily releasable vesicle pool, and replacement of vesicular norepinephrine with tyramine (which functions as a false- or pseudo- neurotransmitter), which when released has no effect on postsynaptic adrenergic receptors (Figure 1)

Nat Rev Gastroenterol Hepatol 19(7):432450