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How much do you actually need for preconception and pregnancy

We proposed the following formula to illustrate how CMS would calculate the AnMP for a Part D rebatable drug as at 428.202(b): (AMP for calendar quarter beginning October) multiplied by (sum of monthly units for October calendar quarter divided by total units for 12-month applicable period) + (AMP for calendar quarter beginning January) multiplied by (sum of monthly units for January calendar quarter divided by total units for 12-month applicable period) + (AMP for calendar quarter beginning April) multiplied by (sum of monthly units for April calendar quarter divided by total units for 12-month applicable period) + (AMP for calendar quarter beginning July) multiplied by (sum of monthly units for July calendar quarter divided by total units for 12-month applicable period) At 428.202(b)(2), we proposed that the first applicable period for a Part D rebatable drug will be the earliest applicable period that follows the payment amount benchmark period identified at 428.202(c)(1) through (4)

(2004) 28:e18

Phase II clinical trials in obese adults (the METAOD series by Metabolic Pharmaceuticals) showed statistically significant weight loss at doses of 1 mg per day orally over 12 weeks compared to placebo