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Our results indicate that the inhibition of SKN-1 is one of the major causes of accelerated aging by exogenous thiols, as NAC shortened the lifespan of daf-16 animals, but failed to do so for skn-1 mutants (Figs

The decisive factor will be which of the mechanisms will prevail

The phylogenetic tree was constructed with BioNJ (Gascuel, 1997) in Seaview and edited with Figtree software ( Subcellular localization The GST subcellular localization was defined based on the available literature, as well as from database mining using TAIR v10, and from the following prediction softwares, Predotar, TargetP, and Wolfpsort