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In line with this, Fento-1 was more potent against HT-1080 cells that were treated with low doses of doxorubicin for a prolonged period of time (Extended Data Fig

In the initiation phase, TLR ligands such as TNF-, IL-1, and HMGB1, which are upregulated in DKD, activate TLRs, subsequently activating IKK through specific signaling pathways