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While B12 is generally safe, caution is needed in specific clinical situations: Lebers Disease (Hereditary Optic Neuropathy): B12 injections are generally contraindicated or should be used with extreme caution, as they may potentially aggravate optic atrophy in this rare condition

The maintenance dose is generally 1500mcg once a month, or at a schedule determined by the physician based on the patient's ongoing clinical needs and blood test results

Check with a healthcare professional before beginning anything.

We have previously demonstrated an increased nicotinamide:nicotinic acid ratio in the adipose tissues of 5A-1MQ-treated DIO mice 13