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These findings together suggest that EZH2/H3K27me3 plays a role in liver failure by regulating immune activation, as evidenced by the fact that GSK126-induced inhibition of EZH2-catalyzed H3K27me3 can significantly attenuate liver injury and reduce inflammatory cell infiltration

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[PMC free article: PMC6573218] [PubMed: 9221791] 133

NKX21 is a direct transcriptional inducer of serine/glycine synthesis enzymes Since NKX21 is a transcription factor, we hypothesised that NKX21 may act as a direct transcriptional activator of serine/glycine synthesis enzyme gene expression