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Description

Many studies used fixed intermittent exposure without full dose-ranging assessment

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and likely the U.S

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These subgroup analyses are shown in Table 12 and Figures 3 and 4

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PMID: 10496658 Svensson J, Lall S, Dickson SL, Bengtsson BA, Rmer J, Ahnfelt-Rnne I, Ohlsson C, Jansson JO

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Because the RFC pathway is less efficient, higher doses of folinic and methylfolate are often required to achieve therapeutic levels in the CSF

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