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This lipolytic effect appears to be mediated through activation of 3-adrenergic receptors on adipocytes, which are G-protein coupled receptors that, when activated, stimulate adenylyl cyclase to increase intracellular cAMP levels
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In particular, [ 68 Ga]Ga-NOTA-Nb1053 showed to be able to identify tumor infiltration in the bone marrow before the presence of overt bone damage
