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This regulatory plasticity drives context-dependent metabolic reprogramming in tumor cells, enabling them to adapt to fluctuating physiological demands or pathological stressors while establishing tumor-specific metabolic signatures critical for survival and progression

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Under normal conditions, NAPQI is detoxified by conjugation with glutathione

Thus, even if there is no demand for NADPH (i.e, .NADP+ is low) and the oxidative phase of the pathway is not active, ribose phosphate can still be generated fromglucose-6-phosphate

38 In esophageal cancer, Liu et al

ZW: Conceptualization, Methodology, Project administration, Supervision, Validation, Visualization, Writing review & editing