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SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE)

synthesized an Fe 3 O 4 magnetic nanoparticle-based nanoplatform for the delivery of the anti-tumor drug vincristine by the functionalization of two ligands, transferrin and folic acid

In the early stage, bacterial metabolic products motivate host cells to release various inflammatory mediators like as IL-1 and TNF-, elevating local oxidative stress levels and increasing the generation of oxygen free radicals by multiple pathways

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Lung tissue oxygenation is compromised as ventilation/perfusion (V/Q) mismatch occurs due to pulmonary edema and elevated peak airway pressures that leads to inadequate ventilation ( At the cellular level, lung IRI is characterized by exacerbation of cellular dysfunction and cell death

Treatment of 24-month-old mice (equivalent to elderly humans) with NNMT inhibitors rescued age-related deficits in muscle stem cell activity