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10,21 Another strategy employed to probe UCHL3 was development of Ub-variants that selectivity target the enzyme over other DUBs 21,22 , although this approach has clear limitations in only being able to dose whole cells with protein

GSTs also have important roles in regulating signaling pathways in a catalytic-independent manner through direct interaction with proteins such as protein kinases to modulate their phosphorylation activities

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In a similar approach, minoxidil and pirenzepine, approved drugs for hypertension and alopecia, and peptic ulcers, respectively, were shown to be neuroprotective

The NF-kappa B signal transduction pathway in aortic endothelial cells is primed for activation in regions predisposed to atherosclerotic lesion formation