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When copper ion levels rise, the functions of these proteins are compromised, accompanied by protein toxicity stress (such as HSP70 induction) and the collapse of mitochondrial metabolism, ultimately leading to cell death (7)

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The test, however, is known to be limited in its specificity to detect cobalamin deficiency because Hcy levels are also elevated by other conditions

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Circulation 120:16401645 Alsaied T, Omar K, James JF et al (2017) Fetal origins of adult cardiac disease: a novel approach to prevent fetal growth restriction induced cardiac dysfunction using insulin like growth factor

Pharmacology of estrogens and progestogens: influence of different routes of administration