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Interestingly, these hub regions which process large amounts of information have high metabolic requirements, are characterized by the co-expression of genes regulating oxidative metabolism, and might be particularly sensitive to OxS [161]

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Results RGMa expression is upregulated in the granular cell layer of the dentate gyrus in db/db mice The db/db mouse, homozygous for spontaneous leptin receptor mutations, has been used as a model of type 2 diabetes mellitus