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Free Radic Res (2011) 45:55967

Its key for doctors to know these differences to choose the best treatment for their patients

Mike Willard of Texas A&M University's College of Veterinary Medicine.) DEFINITIVE DIAGNOSIS Definitively diagnosing a copper-associated hepatopathy requires obtaining a liver biopsy sample surgically or laparoscopically ( Figure 1 ) for histologic examination and copper quantification

Conflict of interest The authors declare that they have no competing financial interests or personal relationships that could have appeared to influence the work reported in this paper

However, the 2 main epigenetic modifications play a major role in determining what genes are expressed: DNA methylation Histone modification These epigenetic modifications are illustrated in the following link