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Despite the observation that up to one-third of patients with psoriasis will develop PsA in their lifetime, PsA is underdiagnosed in patients with psoriasis, and a diagnostic delay of PsA of up to 5 years has been reported [4]

51 For example, integrins, which are transmembrane receptors, mediate the interaction between the extracellular matrix and the cytoskeleton, influencing cell behavior and tissue remodeling