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Future directions for research into the 5Bs include development of predictive models for NP corona formation and composition, and for corona influence on cellular attachment and uptake, biodistribution, bioprocessing and bioclearance, and as well as elucidation of key initiating events and the subsequent adverse outcome pathways related to biomodification resulting from exposure to NPs

The autoimmune reactions caused by immune checkpoint inhibitors appear to be dependent on the pathways targeted, as explained in a paper published in Nature Medicine

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Elkady WM, Ayoub IM, Abdel-Mottaleb Y, ElShafie MF, Wink M

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