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Subfamilies and isoforms can be categorized based on the sequence similarity, domain architecture, quaternary structure, enzymatic activity, ironsulfur cluster binding and the number of active site cysteine residues 1,2,3,4,5

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Besides, there is no conclusive evidence on whether this pathway can be controlled by using a natural antioxidant or anti-inflammatory agent that holds some promise in counteracting TILI

The British National Formulary (BNF), for example, differentiates the prescription of hydroxocobalamin according to presenting symptoms, eg, For neurological involvement, it is advised to administer hydroxocobalamin by intramuscular injection, initially 1 mg once daily on alternate days until no further improvement, then 1 mg every 2 months. In the Netherlands, pharmacotherapeutic guidelines51 recommend (for the same neurological symptoms or abnormalities) administration of 1000 mcg once or twice weekly for up to two years