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Abstract Dietary polyphenols, particularly flavonoids, have been extensively recognized for their role as a source of bioactive molecules that contribute to the prevention of various diseases, including cancer

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Gal3 is able to sense damaged lysosomes, where they accumulate to induce further lysophagy by recruiting autophagy regulatory factors, including uncoordinated-51-like kinase 1 (ULK1), Beclin 1, and autophagy-related protein 16L1 (ATG16L1) after binding with E3 ubiquitin ligase-tripartite domain containing protein 16 (TRIM16) 86

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3.7 Cutting-edge directions and future prospects of astrocytic metabolism research In conclusion, while astrocytes have long been recognized for their supportive roles in the brain, current research is increasingly highlighting their active participation in brain energy metabolism and their potential involvement in neurological disorders

identified the lncRNA LINC01127 as a factor that exerts detrimental effects which is linked to lactylation modifications and LPS produced by the gut microbiota in colorectal cancer patients [150]