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Patients with glaucoma typically exhibit high intraocular pressure (greater than 22 mmHg) and one of the following clinical characteristics

Reduced CI activity has been documented in PD patients as well as in in vitro and in vivo models induced by neurotoxins or genetic factors 84

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Strategies targeting epigenetic modifications have shown promising clinical potential, as they can regulate gene expression, inhibit tumor progression, and provide new therapeutic approaches to combat resistance

Gareau MG, Sherman PM, Walker WA (2010) Probiotics and the gut microbiota in intestinal health and disease

Intranasal adeno-associated virus mediated gene delivery and expression of human iduronidase in the central nervous system: a noninvasive and effective approach for prevention of neurologic disease in mucopolysaccharidosis type I