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Like many medications, hydroxyzine can cause side effects

2002 Aug;132(4):721-8

Broadly, a highly conserved cysteine residue, named the peroxidatic Cys, is the site of oxidant reduction

This is on the higher end, which is why many researchers opt for a more conservative fixed dose to begin

It is particularly concentrated in your liver, which makes sense because the liver is the primary organ responsible for cleaning your blood and removing toxins