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In this study, we conducted MR analysis utilizing the TwoSampleMR software package (version 0.6.8) within the R programming environment.We selected two large plasma pQTLs as exposure data and MS as outcome data

Of note, cells lacking LRP6 alone (LRP6 KO) cannot respond to Wnt (except for the Wnt-induced destabilization of Axin), whereas LRP5 KO cells are as Wnt responsive as their parental controls (Supplementary Fig