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Although the need for dose reduction in the healthy population seems largely unnecessary, it may be warranted in certain severe or decompensated hepatic disease states, particularly if patients are malnourished, are not eating or have a dry weight less than 50 kg

In fact, the Institute of Medicine recommends that adults aged 51 and over take vitamin B12 shots because they are more bioavailable than vitamin B12 found in oral supplements and foods

Clinicians across sports medicine, orthopedics, gastroenterology, and integrative health now prescribe these compounds for tendon and ligament repair, gut-lining restoration, and systemic anti-inflammatory support

A 2020 study found that the death rate among people with the highest levels of B12 in their bodies was almost twice as high as that of people with the lowest levels of B12

57 , e13712 (2024)

Source data of each figure, including uncropped blots, are provided in a single Excel document labeled Source Data