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Crosstalk between autophagy and metabolic regulation of cancer stem cells

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One-carbon metabolism in cancer: moonlighting functions of metabolic enzymes and anti-tumor therapy

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Introduction Among women worldwide, breast cancer accounts for approximately 25% of new cancer diagnoses ( Figure 1 ) ( BRCA1 ), which leads to basal breast cancer ( Figure 1 Literature search strategy and study selection criteria In 2025, a comprehensive literature search was conducted across multiple electronic databases, including Google Scholar, PubMed, SpringerLink, Elsevier ScienceDirect, and Web of Science, to identify relevant studies published between 2015 and 2025