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H(2)S mediates the vasodilator effect of Endothelin-1 in the cerebral circulation

In vivo model of tauopathy and neurodegeneration, Sativex (1:1 CBD:9-THC) reduced iNOS-driven neuroinflammation and oxidative stress independently of CB1/CB2 receptors, underscoring CBDs receptor-agnostic antioxidant properties (Casarejos et al

Reduced oxygen delivery cannot sustain the metabolic demands of the brain tissue, causing necrotic cell death and irreversible damage [8,9]

This helps the immune system regain its ability to differentiate between self and non-self, which is the very essence of resolving autoimmunity